The systemic inflammatory response syndrome (SIRS) is a complex of nonspecific symptoms. SIRS is a life-threatening condition characterized by a mortality rate of 7-25%. At present we lack targeted therapy for SIRS. Additionally treatment decisions in the acute situation often have to be made while being unaware of the underlying pathology or trigger. In the absence of readily available diagnostic tools to guide targeted treatment for paediatric SIRS patients, we have set ourselves the goal of generating personalised immunoprofiles and identifying diagnostic patterns to develop patient-tailored therapies and improve outcome in the long-term. TIPS will be conducted as a multicentre study involving four European countries. With TIPS, we will be able to better classify children with SIRS – opening up a far-reaching perspective for personalised therapy with improved patient outcome and reduction in socio-economic burden.

2021

2024