Drug resistance-induced reprogramming of chromatin and transcription factor activity in prostate cancer

Description of the granted funding

The research proposal aims to characterize how activity of transcription factors is changed during development of drug resistance in prostate cancer. Recent years have brought to the market several very effective cancer drugs. Despite this, many times cancer develops resistance against these drugs. We plan to study how transcription factor activity and chromatin landscape changes in drug resistant prostate cancer. Our research uses genome-wide single-cell genomics and single-molecule live cell imaging in cultured cell lines. Modern bioinformatic analyses are used to build a comprehensive model of transcription factor action during prostate cancer drug resistance. This model will be based on single-cell as well as single-molecule data. The obtained results eventually will have a substantial impact on our understanding of how transcription factors mediate drug resistance and generate new cancer therapy options.
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Starting year

2021

End year

2026

Granted funding

Ville Paakinaho Orcid -palvelun logo
447 650 €

Related funding decisions

361974
Research costs of Academy Research Fellows(2024)
195 844 €
346279
Research costs of Academy Research Fellows(2021)
300 000 €

Funder

Research Council of Finland

Funding instrument

Academy research fellows

Other information

Funding decision number

340927

Fields of science

Biochemistry, cell and molecular biology

Research fields

Solu- ja molekyylibiologia

Identified topics

cancer