Osteoarthritis is the most common joint disease in the world and there is currently no cure available for it. The majority of developed drugs have shown no improvement in patient conditions in clinical trials. The lack of sensitive biomarkers has been proposed as one of the reasons hindering the development of osteoarthritis therapeutics. In this project, we will develop imaging biomarkers reflecting both structural and symptom modifications. Developed biomarkers will be used in preclinical efficacy studies for novel osteoarthritis treatment strategies that target oxygen-sensing in joints.

2022

2027