Every fifth couple in fertile age suffer from involuntary infertility and the number is increasing worldwide. Relatedly, only about 50% of all human embryos produced in infertility clinics throughout the world develop well enough to be transferred to the uterus to initiate pregnancy, while the remaining embryos stop developing or show developmental defects. Mechanisms of early human embryo development are poorly understood due to lack of feasible methods until recently. The aim of this project is to combine data generated by bioinformatics, experimental embryology, and human pluripotent stem cell models to better understand development of human embryos, and challenges related to human reproduction. Information from this project will help us to improve outcomes of infertility treatments and to understand the reasons behind developmental defects.

2022

2027