Development of methods and tools supporting drug repurposing In this project, we will develop computational tools and methods supporting drug repurposing. The project has four computational work packages (WP), and the fifth WP is on experimental validations. The Four computational WPs are summarized as follows: We will develop tools to facilitate the extraction/integration of deep annotations for compounds or biological entities. In WP2, we will develop data-driven web tools and methods to repurpose drugs based on diverse data types such as chemical structures, gene expressions, drug sensitivities, adverse event profiles, drug-target interactions, gene-disease associations, and pathways. These data sets will be extracted with the help of tools/packages (in WP1) and used to devise a scoring method for assessing new indications for approved and investigational drugs. We will use text mining to identify new drug-target interactions from the whole PubMed. In

2022

2026