Obesity is a global health concern and a high-risk factor for various diseases. It leads to insulin resistance, resulting in fat tissue dysfunction and abnormal fat accumulation in organs such as the liver. Macrophages, essential immune cells, play vital roles in obesity-induced organ dysfunction. While macrophages exhibit tissue-specific and subset-specific phenotypes dictated by specific gene expression programs, the impact of alternative splicing—a transcriptional process that generates RNA diversity—on their diverse functions in different tissues remains largely unknown. Our study aims to explore the role of alternative splicing in shaping diverse phenotypes of human macrophages during the development of obesity and insulin resistance. By unraveling the factors driving abnormal splicing, we aspire to contribute to the development of new strategies that enable early diagnosis and intervention in obesity-related diseases, ultimately preventing disease progression into severe stages.

2023

2027