The head part of animals exemplifies a unique interplay between the potential for diversity and the risk of dysfunction, which is relevant to diverse areas ranging from evolution and social interaction to veterinary and clinical genetics. However, because conventional research models such as the mouse are not all-purpose models for human and non-human animal research, there is currently no general understanding of craniofacial diversity and disease. This project will elucidate the mechanisms underlying development, evolution, and diversification of craniofacial tissues in emerging laboratory models (reptiles) with unique life-styles, ecologies and morphologies. Our study will provide relevant new insights into the genetic basis of human birth defects, and will offer excellent opportunities to update conservation strategies for biodiversity protection.

2023

2027