Proper oxygen and nutrient supply are important to avoid diseases, e.g., obesity or type-2 diabetes. We found that an enzyme called USP28 may act as central switch in connecting oxygen and nutrient supply. However, how those connections are made is unknown. Hence, it is the aim of this project to resolve this. Specifically, we want to identify whether switches are made directly, e.g., via other protein partners, or indirectly via genetic modifications, i.e., epigenetic changes. Overall, we think that the results will have therapeutic tractability in obesity, and other diseases.

2023

2027