Soft-tissue sarcomas are a heterogeneous group of tumors, which have precision medicine options poorly available. We have discovered that PDE3A protein is a promising drug target in sarcomas and some target specific drugs kills or halt growth of the tumor cells. The exact molecular mechanisms how the drugs effect on cells are not well understood. In this study, we will investigate molecular mechanisms of the drugs by using various methods, large sarcoma patient sample series, rare cell lines, patient-derived tumor tissue cultures and xenograft mouse models. The aim of the study is to discover the molecular mechanisms of PDE3A specific drugs in cancer cells, which will led us to find novel therapy targets, develop diagnostics methods and enable development of the first precision medicine approach for many sarcoma types with a high unmet need for efficacious therapies.

2023

2027