Pharmaceutical residues are ubiquitous in the aquatic environment all over the world. In the environment, these residues can bioaccumulate and cause severe adverse effects on aquatic organisms, especially fish. Majority of these residues arise from human use, i.e., drugs excreted to wastewaters. In this project, we develop new in vitro technology that could help predict the mechanistic basis of the pharmaceuticals' adverse impacts on fish on cellular and molecular levels. In the future, such mechanism-based information could be exploited e.g., to predicting the combined impacts of pharmaceuticals mixtures or to design new drug molecules that are inherently less harmful for the environment.

2025

2029