Bioengineered ß-glucan for cardiac pre-conditioning: Molecular mechanism and pharmaceutical approaches thereof

Description of the granted funding

Cardiovascular diseases (CVDs) represent major healthcare burdens for Finnish people. Instead of focusing on treatment after heart attacks occur, this project aims alternative ways. This project aims to bioengineer a natural substance, ß-glucan (derived from barley), into an oral formulation, and this can “train” our body to better resist heart damage. This may generate a simple, affordable mini-capsules that can be taken daily, so no injections or complex procedures needed. I will produce the engineered ß-glucan formulations using a method named microfluidics, which has been used by creating COVID-19 vaccines, and conduct laboratory studies to see how they affect heart cells under stress. By understanding the biological mechanisms behind this protective effect, I hope to discover a new, preventive strategy against CVDs. Hopefully, this finding could lower healthcare costs, improve patient quality of life, and open new directions in cardiovascular prevention.
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Starting year

2025

End year

2029

Granted funding

Zehua Liu Orcid -palvelun logo
670 104 €

Funder

Research Council of Finland

Funding instrument

Academy research fellows

Decision maker

Scientific Council for Biosciences, Health and the Environment
16.06.2025

Other information

Funding decision number

370362

Fields of science

Pharmacy

Research fields

Farmasia

Identified topics

diabetes, medicine, metabolic diseases