Bioengineered ß-glucan for cardiac pre-conditioning: Molecular mechanism and pharmaceutical approaches thereof
Description of the granted funding
Cardiovascular diseases (CVDs) represent major healthcare burdens for Finnish people. Instead of focusing on treatment after heart attacks occur, this project aims alternative ways. This project aims to bioengineer a natural substance, ß-glucan (derived from barley), into an oral formulation, and this can “train” our body to better resist heart damage. This may generate a simple, affordable mini-capsules that can be taken daily, so no injections or complex procedures needed. I will produce the engineered ß-glucan formulations using a method named microfluidics, which has been used by creating COVID-19 vaccines, and conduct laboratory studies to see how they affect heart cells under stress. By understanding the biological mechanisms behind this protective effect, I hope to discover a new, preventive strategy against CVDs. Hopefully, this finding could lower healthcare costs, improve patient quality of life, and open new directions in cardiovascular prevention.
Show moreStarting year
2025
End year
2029
Granted funding
Funder
Research Council of Finland
Funding instrument
Academy research fellows
Decision maker
Scientific Council for Biosciences, Health and the Environment
16.06.2025
16.06.2025
Other information
Funding decision number
370362
Fields of science
Pharmacy
Research fields
Farmasia
Identified topics
diabetes, medicine, metabolic diseases