Insulin resistance, a key feature of type 2 diabetes and obesity, refers to the body's reduced ability to store nutrients as insulin levels rise. In tissues such as muscle and adipose tissue, this manifests as impaired glucose (sugar) storage. However, in the brain, an increase in insulin levels paradoxically leads to increased glucose utilization in individuals with insulin resistance, for reasons that remain unclear. This phenomenon is also associated with functional and structural changes in the brain, but integrating different methods to form a comprehensive understanding is still ongoing. Given the increased risk of neurodegenerative diseases and mental health issues associated with type 2 diabetes, it is crucial to gain a deeper understanding of what happens in the brain during insulin resistance.

2025

2029