Endolysosomal network in B cell activation and immunity: Decoding novel signaling roles and antigen processing
Description of the granted funding
B cell activation is the driving trigger towards mounting of antibody responses. In this project, we will tackle the previously unknown questions about the mechanism of early B cell activation initiated by recognition of specific antigens. We will examine the novel functions of the intracellular vesicle network, namely lysosomes and their regulation by septins, in the regulation of B cell activation. We aim to reveal molecular level insights to build better basic understanding of the cellular requirements behind immune responses. To reveal the therapeutic potential of inhibiting lysosomal activities in B cell pathologies, we examine the effects of targeting these pathways in clinical samples of B cell lymphoma or B cells isolated from the inflamed joints of patients with rheumatoid arthritis. Moreover, we will examine the viral antigen processing upon B cell activation to understand the molecular details behind successful vaccination responses.
Show moreStarting year
2025
End year
2029
Granted funding
Funder
Research Council of Finland
Funding instrument
Academy projects
Decision maker
Scientific Council for Biosciences, Health and the Environment
16.06.2025
16.06.2025
Other information
Funding decision number
371018
Fields of science
Biomedicine
Research fields
Biolääketieteet