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Exploration of Pyrazolo[1,5-a]pyrimidines as Membrane-Bound Pyrophosphatase Inhibitors

Peer-reviewed
Open access
DOI
10.1002/cmdc.202100392
Johansson, Niklas G; Dreano, Loic; Vidilaseris, Keni; Khattab, Ayman; Liu, Jianing; Lasbleiz, Arthur...
Chemmedchem2021

Multisubstituted pyrimidines effectively inhibit bacterial growth and biofilm formation of Staphylococcus aureus

Peer-reviewed
Open access
DOI
10.1038/s41598-021-86852-5
Provenzani, Riccardo; San-Martin-Galindo, Paola; Hassan, Ghada; Legehar, Ashenafi; Kallio, Aleksi On...
Scientific Reports2021

DNA binding, artificial nuclease activity and cytotoxic studies of newly synthesized steroidal pyrimidines

Peer-reviewed
DOI
10.1016/j.ijbiomac.2017.12.128
Dar, Ayaz Mahmood; Rah, Bilal; Mir, Shafia; Nabi, Rizwan; Shamsuzzaman, Md. Mostafa ; Gatoo, Manzoor...
International Journal of Biological Macromolecules2018

Scaffold hopping from (5-hydroxymethyl) isophthalates to multisubstituted pyrimidines diminishes binding affinity to the C1 domain of protein kinase C

Peer-reviewed
Open access
DOI
10.1371/journal.pone.0195668
Provenzani, Riccardo; Tarvainen, Ilari Matti Elias; Brandoli, Giulia; Lempinen, Antti Tapani; Artes,...
PLoS One2018

2-Acylamino- and 2,4-bis(acylamino)pyrimidines as supramolecular synthons analysed by multiple non-covalent interactions. DFT, X-ray diffraction, and NMR spectral studies

Peer-reviewed
DOI
10.1021/jo301643z
Osmialowski, Borys; Kolehmainen, Erkki; Ikonen, Satu; Valkonen, Arto; Kwiatkowski, Adam; Grela, Izab...
The Journal of Organic Chemistry2012

Electro-organic synthesis of C-5 sulfenylated amino uracils: Optimization and exploring topoisomerase-I based anti-cancer profile

Peer-reviewed
DOI
10.1016/j.bioorg.2023.106660
Rani, Payal; Chahal, Sandhya; Kumar, Roshan; Mayank; Kumar, Parvin; Negi, Arvind; Singh, Rajvir; Kum...
Bioorganic Chemistry2023

Inhibition of HSD17B13 protects against liver fibrosis by inhibition of pyrimidine catabolism in nonalcoholic steatohepatitis

Peer-reviewed
Open access
DOI
10.1073/pnas.2217543120
Luukkonen, Panu K.; Sakuma, Ikki; Gaspar, Rafael C.; Mooring, Meghan; Nasiri, Ali; Kahn, Mario; Zhan...
Proceedings of the National Academy of Sciences of the United States of America2023

DPYD-geenitestaus kliinisessä käytössä

Peer-reviewed
Open access
Saarenheimo, Jatta; Wahid, Nesna; Tornio, Aleksi; Ristamäki, Raija; Keinänen, Mauri; Niemi, Mikko; T...
Duodecim2021

Exploration of Pyrazolo[1,5-a]pyrimidines as Membrane-Bound Pyrophosphatase Inhibitors

Peer-reviewed
Open access
DOI
10.1002/cmdc.202100392
2021

Multisubstituted pyrimidines effectively inhibit bacterial growth and biofilm formation of Staphylococcus aureus

Peer-reviewed
Open access
DOI
10.1038/s41598-021-86852-5
2021

DNA binding, artificial nuclease activity and cytotoxic studies of newly synthesized steroidal pyrimidines

Peer-reviewed
DOI
10.1016/j.ijbiomac.2017.12.128
2018

Scaffold hopping from (5-hydroxymethyl) isophthalates to multisubstituted pyrimidines diminishes binding affinity to the C1 domain of protein kinase C

Peer-reviewed
Open access
DOI
10.1371/journal.pone.0195668
2018

2-Acylamino- and 2,4-bis(acylamino)pyrimidines as supramolecular synthons analysed by multiple non-covalent interactions. DFT, X-ray diffraction, and NMR spectral studies

Peer-reviewed
DOI
10.1021/jo301643z
2012

Electro-organic synthesis of C-5 sulfenylated amino uracils: Optimization and exploring topoisomerase-I based anti-cancer profile

Peer-reviewed
DOI
10.1016/j.bioorg.2023.106660
2023

Inhibition of HSD17B13 protects against liver fibrosis by inhibition of pyrimidine catabolism in nonalcoholic steatohepatitis

Peer-reviewed
Open access
DOI
10.1073/pnas.2217543120
2023

DPYD-geenitestaus kliinisessä käytössä

Peer-reviewed
Open access
2021