Interplay of synaptic changes, neuroinflammation and beta-amyloid in cognitively normal subjects with varying risk of late-onset Alzheimer’s disease (ASIC-E4) – Metadata

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Interplay of synaptic changes, neuroinflammation and beta-amyloid in cognitively normal subjects with varying risk of late-onset Alzheimer’s disease (ASIC-E4) – Metadata

Description

This dataset contains imaging and biomarker measures from cognitively unimpaired volunteers with varying risk for AD due to different APOE genotypes (N=63). The dataset includes the following measurements: - Brain PET imaging using 11C-PiB (targeting beta-amyloid), 11C-PK11195 (targeting 18 kDa translocator protein) and 11C-UCB-J (targeting SV2a). - Structural and functional brain magnetic resonance imaging - Blood biomarker measurements (Abeta, tau, p-tau, NTA-tau, GFAP, NfL) - Neuropsychological testing - Laboratory measurements Study protocol and baseline characteristics have been published and are openly available (Snellman A et al., Front Neurol. 2022 Feb 9;13:826423. doi: 10.3389/fneur.2022.826423. eCollection 2022.)
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Year of publication

2023

Authors

Turku PET Centre

Juha Rinne - Creator

Turku University Hospital Catchment Area - Rights holder
University of Turku

Anniina Snellman Orcid -palvelun logo - Creator, Publisher

Other information

Fields of science

Biomedicine; Neurosciences

Language

English, Finnish

Open access

Open

Keywords

Alzheimer's disease, Alzheimerin tauti, APOE, beeta-amyloidi, neuroinflammaatio, PET, synapsi

Subject headings

apolipoproteins, biomarkers, magnetic resonance imaging, positron emission tomography
Interplay of synaptic changes, neuroinflammation and beta-amyloid in cognitively normal subjects with varying risk of late-onset Alzheimer’s disease (ASIC-E4) – Metadata - Research.fi