Biological constraints for parameter values of large-scale biologically plausible human Neuroscience models

Biological constraints for parameter values of large-scale biologically plausible human Neuroscience models

Description

This dataset contains 1.) time constants of excitatory and inhibitory neocortical neurons, collated from the NeuroElectro database, 2.) spike thresholds of excitatory and inhibitory neurons, collated from the NeuroElectro database, and 3.) posterior distributions of parameters of large-scale biologically plausible models of human Neuroscience data, estimated using likelihood-free inference (LFI) methods to fit these models to Magnetoencephalography (MEG) resting-state data (N=75). We used pooled versions of the time constants and spike threshold values in this dataset along with other biological constraints, to set prior distributions of parameters of large-scale biologically plausible models of human Neuroscience data. We then used LFI methods to estimate posterior distributions of these parameters from MEG resting-state data (N=75) - we have also shared the posterior distributions in this dataset. Examples of parameters for which we have shared posterior distributions include strengths of connections within and between excitatory and inhibitory neuronal populations, time constants of excitatory and inhibitory neuronal populations, and firing thresholds of excitatory and inhibitory neuronal populations. These posterior distributions could be used by other research groups to set prior distributions of parameters of their biologically plausible models, in both experimental and modeling studies.
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Year of publication

2023

Authors

Department of Neuroscience and Biomedical Engineering

Nitin Williams - Creator

Anttoni Ojanperä - Contributor

Benedetta Toselli - Contributor

Felix Siebenhühner - Contributor

Gabriele Arnulfo - Contributor

Matias Palva Orcid -palvelun logo - Contributor

Samuel Kaski Orcid -palvelun logo - Contributor

Satu Palva - Contributor

Mendeley Data - Publisher

University of Manchester - Contributor

Other information

Open access

Open

License

Creative Commons Attribution 4.0 International (CC BY 4.0)