Supplementary Material for: Association of Torquetenovirus viremia with physical frailty and cognitive impairment in three independent European cohorts

Description

Introduction: Immunosenescence and inflammaging have been implicated in the pathophysiology of frailty. Torquetenovirus (TTV), a single-stranded DNA anellovirus, the major component of the human blood virome, shows an increased replication rate with advancing age. An elevated TTV viremia has been associated with an impaired immune function and an increased risk of mortality in the older population. The objective of this study was to analyze the relation between TTV viremia, physical frailty and cognitive impairment Methods: TTV viremia was measured in 1131 nonfrail, 45 physically frail, and 113 cognitively impaired older adults recruited in the MARK-AGE study (overall mean age 64.7±5.9 years), then the results were checked in two other independent cohorts from Spain and Portugal, including 126 frail, 252 prefrail and 141 nonfrail individuals (overall mean age: 77.5±8.3 years). Results: TTV viremia ≥4log was associated with physical frailty (OR: 4.69; 95% CI: 2.06-10.67, p

Year of publication

2023

Authors

Tampere University

Antti Hervonen - Creator

Mikko Hurme - Creator

Unknown organization

Alexander Bürkle - Contributor

Ana Maseda - Contributor

Armanda Teixeira-Gomes - Contributor

Birgit Weinberger - Contributor

Blanca Laffon - Contributor

Christiane Schön - Contributor

Claudio Franceschi - Contributor

Eduardo Pásaro - Contributor

Efstathios S. Gonos - Contributor

Eugène Jansen - Contributor

Ewa Sikora - Contributor

Fabrizio Maggi - Contributor

Florence Debacq-Chainiaux - Contributor

Francesco Piacenza - Contributor

Joao Paulo Teixeira - Contributor

José Carlos Millán-Calenti - Contributor

Jürgen Bernhardt - Contributor

Laura Lorenzo-López - Contributor

Lisa MacEra - Contributor

M. Liset Rietman - Contributor

Marco Malavolta - Contributor

Martijn E.T. Dollé - Contributor

María Moreno-Villanueva - Contributor

Mauro Provinciali - Contributor

Miriam Capri - Contributor

Nicolle Breusing - Contributor

Olivier Toussaint - Contributor

P. Eline Slagboom - Contributor

Pietro Giorgio Spezia - Contributor

Robertina Giacconi - Contributor

Solange Costa - Contributor

Stefano Bonassi - Contributor

Tilman Grune - Contributor

Vanessa Valdiglesias - Contributor

Wolfgang Stuetz - Contributor

figshare - Publisher

Other information

Fields of science

General medicine, internal medicine and other clinical medicine

Language

English

Open access

Open

License

Creative Commons Attribution 4.0 International (CC BY 4.0)

Keywords

Internal medicine