Comprehensive Molecular Annotation of Adverse Outcome Pathways Related to Human Health

Comprehensive Molecular Annotation of Adverse Outcome Pathways Related to Human Health

Description

Adverse Outcome Pathways (AOPs) are multi-scale models of biological mechanisms connecting molecular initiating events to adverse outcomes through measurable key events. AOPs can guide the use and development of new approach methodologies (NAMs) aimed at reducing animal experimentation in chemical safety assessment. Here, we present a comprehensive molecular annotation of AOPs relevant to human health to embed the AOP framework into molecular data interpretation, which supports the development and application of novel AOP-based approaches in biomedical research.
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Year of publication

2022

Authors

Laura Saarimäki - Creator

Alisa Pavel - Contributor

Angela Serra - Contributor

Dario Greco - Contributor

Michele Fratello - Contributor

Unknown organization

Seela Korpilähde - Contributor

Zenodo - Publisher

Other information

Fields of science

Biomedicine

Language

English

Open access

Open

License

Creative Commons Attribution 4.0 International (CC BY 4.0)

Keywords

Biomedicine
Comprehensive Molecular Annotation of Adverse Outcome Pathways Related to Human Health - Research.fi