The intestine is emerging as a key regulator of animal metabolism. Signals derived from the intestine (e.g. hormones) have critical roles in organ-to-organ crosstalk and they control organismal metabolism. The intestinal metabolism and signaling are closely coupled to nutrition, but the underlying molecular mechanisms remain poorly understood. In this project, I will explore a novel redox-based sugar sensing mechanism and its role in cellular homeostasis, metabolism and signaling of the intestine. This work will uncover new insight into nutrient-dependent control of animal physiology with potential relevance to human disease.

2020

2023