This project studies how platelets, the small cell fragments that stop bleeding upon vascular damage, are loaded with distinct RNAs to enable their function in blood clotting. Although platelets lack a nucleus, and thus cannot produce their own RNA, they contain a rich repertoire of RNAs derived from their parent cell. By utilising innovative biochemical, cell biological, imaging and bioinformatics techniques, this project generates revolutionary knowledge on RNA sorting into platelets and the role of distinct RNAs in platelet function. Platelet disorders are life-threatening and can only temporarily be treated by platelet transfusions. Platelet RNA may also be leveraged in diagnostics to identify molecular mechanisms that control human disease. Thus, understanding the underlying mechanisms of platelet RNA biology has great potential in improving human health and leading to biotechnological innovations to treat platelet disorders and may open avenues for novel diagnostic approaches.

2022

2024