Large epidemiological studies have demonstrated the beneficial health effects of exercise, but relatively little is known about the molecular mechanisms mediating these effects, especially in other tissues than skeletal muscle. This information would be important to identify mechanisms that could be targeted to treat cardiometabolic diseases. As vasculature is present in all tissues, we hypothesise that endothelial cells, which line the inside of blood vessels, would have an important role in mediating the detrimental effects of cardiometabolic disease and the health benefits of exercise in various tissues. Here, we will examine the effects of ageing, obesity and cardiometabolic disease on endothelial cells and their secreted factors in mouse models, cell culture systems and in patients, who will undergo a 1-year intervention at the Exercise Medicine Clinic. Our aim is to identify novel therapeutic targets for cardiometabolic disease in endothelial cells.

2022

2026