Human genetics has proven to be instrumental for identifying novel molecular mechanisms underlying common complex diseases and holds the promise of improved, targeted treatment as well as prediction, prevention and diagnosis. Building on unique resources and extensive track record in disease genetic studies in Finland, the Centre of Excellence in Complex Disease Genetics (CoECDG) develops and applies strategies for the identification of risk and protective variants, with focus on high-impact low-frequency alleles that contribute significantly to common diseases, and to implement strategies for genomic precision medicine. The CoECDG will also lead national efforts to implement genomic findings into prevention and personalized treatment of common complex diseases. In our second funding term, we expand our activities to new disease areas and develop strategies for better understanding the mechanisms through which genes contribute to disease, disease progression and treatment responses.

2023

2025