Psychotic disorders are severe mental disorders with profound effects on performance and on quality of life. Given the neurodevelopmental origin of the most common psychotic disorder, schizophrenia, and the related structural and functional deficits, one can anticipate that the recovery processes during sleep, important for maintaining and improving brain plasticity, would be of particular importance for the patients. Our objective is to evaluate the role of adequate sleep and undisturbed circadian rhythms in the disease course and identify specific sleep-related EEG-based traits for the disease symptoms, and to map these traits to underlying processes of disturbed cognition and regulation of emotions. The study will give novel insight into the role of sleep and circadian rhythms in the disease trajectory from early psychosis to chronic SZ and, eventually, tools for clinical practice in treatment of SZ and other psychotic disorders.

2023

2027