Viruses with RNA genomes cause most of the emerging and re-emerging infectious disease epidemics. The project aims to establish a comprehensive view of host interaction during virus replication by identifying host proteins that assist in virus replication. We aim to understand the specific actions that each host factor performs during virus replication. The proteins could assist e.g. in the modification of host cell membranes, as viruses rearrange the membranes to create protective replication vesicles. The host proteins important for virus replication are attractive new targets for antiviral drugs that could act broadly against several virus families.

2024