Neurological disorders like Alzheimer’s and Parkinson’s disease have significant personal costs for those affected and pose a considerable socioeconomic challenge worldwide. There are no treatments available to modify disease progression. Several neurological disorders have a common defect in a cellular recycling process termed autophagy. The project aims to study a recently discovered group of patients with genetic impairments in autophagy, to understand how they adapt and survive despite defects in a key homeostatic mechanism. The research aims to uncover new knowledge and therapeutic targets that could help defeat degeneration.

2024