This project aims to understand how mitochondrial cristae are formed. Mitochondria are known as the powerhouses of the cell because they generate energy. Cristae, which are the folds inside the mitochondria, change shape depending on the metabolic activity of mitochondria. It is technically difficult to track the formation of these folds in living cells. We use a unique experimental approach and super-resolution microscopy to provide a systematic study of mitochondrial cristae formation. Our research will contribute to the understanding of associated human diseases, particularly those impacting the brain, such as neurodegenerative diseases.

2024