Diabetes is an alarming global health problem that requires innovative therapeutic solutions. Current treatments fall short, as they do not resolve the primary disease mechanisms behind impaired insulin secretion. Recent advances in stem cell technology make possible the generation of insulin-secreting cells in the lab. However, these stem cell-derived cells are immature due to our limited understanding of how they fully develop naturally. The aim of this project is to gain insights into the mechanisms that orchestrate human pancreas development by combining data generated with state-of-the-art technologies, including stem cell models, single-cell analytics and editing of the genetic code. This novel information will help us to improve the generation of stem cell-derived insulin-secreting cells for therapy and disease modeling, translating into better diagnostic and treatment tools for diabetes. The project will be conducted at the Faculty of Medicine, University of Helsinki.

2024

2028