There is a huge need for the development of effective treatments for Alzheimer's disease (AD). The project's aim is to explore new molecular mechanisms underlying AD pathogenesis to identify new drug targets and shed light on differences in AD development and progression in men and women. In the present project, we will systematically investigate the role of transporters in the brain and peripheral removal of amyloid-ß (Aß) in AD. The accumulation of Aß in the brain is one of the major hallmarks of AD, which is partly resulted from the reduced removal of Aß from the brain. Here, we will use state-of-the-art proteomics analysis with mass spectrometry to identify associations between changes in transporter expression and Aß pathology in human postmortem AD brains and a rat model of AD, which manifests the full array of AD pathological features present in the patients. The research will be conducted at the University of Eastern Finland in collaboration with Leiden University.

2024

2028