Evidence suggests that gut bacteria may determine the levels of many molecules in our blood. In recent studies, I and, others have shown that children who develop type 1 diabetes (T1D) later in life are characterized by disturbances in blood lipid molecules and gut bacteria, suggesting that there is an interplay between host metabolism, the immune system, and the gut bacteria during the early T1D pathogenesis. However, prospective human data bridging gut lipids and bacteria in context of T1D is largely lacking. Thus, the theme of this project is to assess how the gut related lipids and microbiome interact in relation to T1D development. This project will provide integrated data for the purposes of both interventions and mechanistic experiments via applying advanced data analysis techniques to the human cohort data. The ultimate aim is to identify novel targets for preventive and treatment interventions for T1D.

2024

2028