RNA viruses cause most of the new and re-emerging disease epidemics, which often spread in both humans and animals. Viruses recruit many cellular proteins to assist in viral replication. We have identified a large set of host cell proteins, which bind to alphavirus replication proteins. Alphaviruses are mosquito-borne viruses, and different alphaviral species are found worldwide (Sindbis virus causes Pogosta disease in Finland). Our aim is to comprehensively analyze inhibition of host proteins as antiviral strategy. We will search for inhibitors of the identified host proteins in databases, and test the inhibitors in cell culture against several alphaviruses. The most promising molecules will be tested in combinations, since efficient treatment virus infection usually requires combination therapy. By targeting host cell functions, it is possible to achieve broad-spectrum antivirals, against which the viruses cannot develop resistance.

2024

2028