Sudden cardiac deaths are among the most common causes of death worldwide. Arrhythmias cause cardiac arrest due to structural or electrical problems of the heart. The range of arrhythmias is broad, and their causes are largely unexplained. Hereditary factors play a significant role, but they are poorly understood. Effective prevention and treatment require a better understanding of disease mechanisms and new, more accurate tools for diagnostics. Newly identified serum auto-antibody discoveries may bring a breakthrough. We recently described a human-like arrhythmia and antibody discovery also in dogs. This points to similarities in the background of arrhythmias and opens up possibilities for elucidating the causes across species. We intend to develop an antibody detection test for dogs, with the help of which we will build research material for elucidating gene discoveries and disease mechanisms in dogs. The findings are compared with human patients to develop new treatment methods.

2024

2028