A dynamic view of protein complexes: A new approach for the treatment of neurodegenerative diseases
Description of the granted funding
This project examines protein complexes that are associated to neurodegenerative diseases using high performance computing. The aim is to explore the dynamic changes in complexes due to the inhibitors or stimulators of various proteins. The protein regulators can have major impact on protein dynamics which also effects on the protein complex. This study focus on protein phosphatase 2 (PP2A) and its regulator proteins, Prolyl oligopeptidase (PREP) and Midline1 (MID1). We will study the protein complexes by applying the protein-protein docking tools and the stability and dynamics of complexes with molecular dynamics.
Show moreStarting year
2025
End year
2027
Granted funding
Funder
Research Council of Finland
Funding instrument
Targeted Academy projects
Decision maker
Suomen akatemian muu päättäjä
18.12.2024
18.12.2024
Other information
Funding decision number
364622
Fields of science
Chemical sciences
Research fields
Orgaaninen kemia