Thyroid disorders are common diseases that affect more than 200 million people worldwide. The thyroid gland produces and secretes hormones, which are essential for adult health and childhood brain development, as well as growth. Even small deviations from the normal range in thyroid hormone levels are associated with an increased risk of cardiovascular morbidity and mortality, dyslipidemia, obesity, fractures, and a lifetime risk of cancer. The overall goal of our study is to provide novel information regarding the etiology and mechanisms of thyroid diseases. We aim to achieve this by studying patients with familial thyroid diseases, such as congenital hypo- or hyperthyroidism, and by using genetically modified animals as models. The identification of new gene mutations in these patients and the characterization of these mutations in vivo or in vitro will shed light on the pathogenesis of thyroid disorders and contribute to the development of therapeutic approaches.

2023

2024