Understanding the intranuclear mechanisms of herpesvirus reactivation and its effects on host chromatin structure and dynamics is crucial for basic research and the development of oncolytic virus therapies and novel antivirals aimed at blocking virus reactivation. This project aims to refine the understanding of the mechanisms of virus reactivation and the roles of chromatin organization and phase separation in this process. The research will be conducted at the University of Jyväskylä, using an interdisciplinary approach that combines cell biology and biophysics with advanced imaging techniques, protein structure prediction algorithms, and biophysical modeling.

2025

2029