Endometriosis is a chronic inflammatory disease affecting about one in ten women, yet its causes remain largely unknown. Growing evidence suggests that long-term exposure to endocrine-disruptive chemicals, such as bisphenols, phthalates, and dioxins, may disturb hormonal and immune signaling, contributing to the onset or progression of the disease. The EIRIS project will combine large-scale literature mining, and molecular biology to uncover how these chemicals affect endometrial cells at the molecular level. By integrating results from published studies, public omics databases, and new laboratory experiments, EIRIS will build the first mechanistic map of chemical-induced endometriosis. This open, data-driven framework will clarify disease mechanisms, identify biomarkers of chemical exposure, and support the development of safer chemicals and non-animal methods for risk assessment, advancing both women's health and regulatory toxicology.

2026

2030