The protective PLCγ2-P522R variant mitigates Alzheimer’s disease-associated pathologies by enhancing beneficial microglial functions

Year of publication

2025

Authors

Takalo, Mari; Jeskanen, Heli; Rolova, Taisia; Kervinen, Inka; Hellén, Marianna; Heikkinen, Sami; Koivisto, Hennariikka; Jokivarsi, Kimmo; Müller, Stephan A.; Koivumäki, Esa-Mikko; Mäkinen, Petra; Juopperi, Sini-Pauliina; Willman, Roosa-Maria; Sinisalo, Rosa; Hoffmann, Dorit; Jäntti, Henna; Peitz, Michael; Fließbach, Klaus; Kuulasmaa, Teemu; Natunen, Teemu; Kemppainen, Susanna; Poutiainen, Pekka; Leinonen, Ville; Malm, Tarja; Martiskainen, Henna; Ramirez, Alfredo; Haapasalo, Annakaisa; Lichtenthaler, Stefan F.; Tanila, Heikki; Haass, Christian; Rinne, Juha; Koistinaho, Jari; Hiltunen, Mikko

Organizations and authors

University of Helsinki

Koistinaho Jari

Hellen Marianna

Rolova Taisia

University of Turku

Rinne Juha

Koivumäki Mikko

University of Eastern Finland

Haapasalo Annakaisa

Hoffmann Dorit Bettina

Tanila Heikki Juhani

Jäntti Henna Johanna

Koivisto Hennariikka

Jokivarsi Kimmo Tapani

Malm Tarja Maarit

Jeskanen Heli Anniina

Martiskainen Henna Maria

Kervinen Inka

Takalo Mari Anna

Hiltunen Mikko Juhani

Mäkinen Petra Maria

Willman Roosa-Maria

Sinisalo Rosa Marie

Heikkinen Sami Pekka

Juopperi Sini-Pauliina Eveliina

Kemppainen Susanna Lea Annikki

Natunen Teemu Antero

Leinonen Ville

Publication type

Publication format

Article

Parent publication type

Journal

Article type

Original article

Audience

Scientific

Peer-reviewed

Peer-Reviewed

MINEDU's publication type classification code

A1 Journal article (refereed), original research

Publication channel information

Journal/Series

Journal of neuroinflammation

Parent publication name

Journal of Neuroinflammation

Volume

Issue

Article number

ISSN

1742-2094

Publication forum

61141

Publication forum level

Open access

Open access in the publisher’s service

Yes

Open access of publication channel

Fully open publication channel

Self-archived

Yes

License of the self-archived publication

CC BY

Other information

Fields of science

Biomedicine; Neurosciences; Neurology and psychiatry; Surgery, anesthesiology, intensive care, radiology

Publication country

United Kingdom

Internationality of the publisher

International

Language

English

International co-publication

Yes

Co-publication with a company

DOI

10.1186/s12974-025-03387-6

The publication is included in the Ministry of Education and Culture’s Publication data collection

Yes