Short non-coding RNAs (sncRNAs) expression has been connected to the development of cardiometabolic diseases (CMDs), and they have been hypothesized to convey the inheritance of acquired traits. CMDs are causing an overwhelming burden on the health care systems of countries with aging populations, but these diseases are becoming more prevalent in younger individuals as well. We will study what is a physiological sncRNA profile and whether changes in levels of sncRNAs convey the accumulative risk of CMDs. We will also investigate whether father's lifestyle and phenotype can lead to phenotypic changes in the offspring via sperm sncRNA and how offspring's adulthood sncRNA are affected by conditions during their gestation. Our aim is to find novel biomarkers for CMDs and to identify individuals and families in increased risk and add to the information on how parental phenotype during conception and pregnancy effect child's future health.

2021

2026