Mitochondria are cell organelles with multiple important roles in cell biology, physiology and biochemistry. Recent research results have indicated that mitochondrial acyl carrier protein ACP with acyl-group is essential for assembly or function of respiratory complexes, synthesis of lipoate and iron-sulfur complexes and mitochondrial protein synthesis. Mitochondrial fatty acid synthesis (mtFAS) generates the acyl-groups depending on the nutritional status of a cell. Currently, mtFAS is regarded as a sensor and a transmitter from mitochondrial intermediary metabolism to mitochondrial respiration. Precise mechanism how this transmission works is not known. In this project we will study the role of different chain-length acyl-ACPs for mitochondrial and cellular function. We use yeast and human induced pluripotent stem cells as models. Based on the results from this project we will understand how acyl-ACPs regulate mitochondrial and cellular functions.

2024

2028