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Accelerated size-focusing light activated synthesis of atomically precise fluorescent Au22(Lys–Cys–Lys)16 clusters

Year of publication

2024

Authors

Aminfar, Parimah; Ferguson, Travis; Steele, Emily; MacNeil, Emerson M.; Matus, María Francisca; Malola, Sami; Häkkinen, Hannu; Duchesne, Paul N.; Loock, Hans-Peter; Stamplecoskie, Kevin G.

Abstract

Atomically precise metal nanoclusters are promising candidates for various biomedical applications, including their use as photosensitizers in photodynamic therapy (PDT). However, typical synthetic routes of clusters often result in complex mixtures, where isolating and characterizing pure samples becomes challenging. In this work, a new Au22(Lys–Cys–Lys)16 cluster is synthesized using photochemistry, followed by a new type of light activated, accelerated size-focusing. Fluorescence excitation–emission matrix spectroscopy (EEM) and parallel factor (PARAFAC) analysis have been applied to track the formation of fluorescent species, and to assess optical purity of the final product. Furthermore, excited state reactivity of Au22(Lys–Cys–Lys)16 clusters is studied, and formation of type-I reactive oxygen species (ROS) from the excited state of the clusters is observed. The proposed size-focusing procedure in this work can be easily adapted to conventional cluster synthetic methods, such as borohydride reduction, to provide atomically precise clusters.
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Organizations and authors

University of Jyväskylä

Häkkinen Hannu

Matus Cortés Maria Orcid -palvelun logo

Malola Sami

Publication type

Publication format

Article

Parent publication type

Journal

Article type

Original article

Audience

Scientific

Peer-reviewed

Peer-Reviewed

MINEDU's publication type classification code

A1 Journal article (refereed), original research

Publication channel information

Volume

16

Issue

1

Pages

205-211

​Publication forum

63714

​Publication forum level

3

Open access

Open access in the publisher’s service

No

Self-archived

Yes

Other information

Fields of science

Physical sciences; Nanotechnology

Keywords

[object Object],[object Object]

Publication country

United Kingdom

Internationality of the publisher

International

Language

English

International co-publication

Yes

Co-publication with a company

No

DOI

10.1039/d3nr04793h

The publication is included in the Ministry of Education and Culture’s Publication data collection

Yes