Accelerated size-focusing light activated synthesis of atomically precise fluorescent Au22(Lys–Cys–Lys)16 clusters
Year of publication
2024
Authors
Aminfar, Parimah; Ferguson, Travis; Steele, Emily; MacNeil, Emerson M.; Matus, María Francisca; Malola, Sami; Häkkinen, Hannu; Duchesne, Paul N.; Loock, Hans-Peter; Stamplecoskie, Kevin G.
Abstract
Atomically precise metal nanoclusters are promising candidates for various biomedical applications, including their use as photosensitizers in photodynamic therapy (PDT). However, typical synthetic routes of clusters often result in complex mixtures, where isolating and characterizing pure samples becomes challenging. In this work, a new Au22(Lys–Cys–Lys)16 cluster is synthesized using photochemistry, followed by a new type of light activated, accelerated size-focusing. Fluorescence excitation–emission matrix spectroscopy (EEM) and parallel factor (PARAFAC) analysis have been applied to track the formation of fluorescent species, and to assess optical purity of the final product. Furthermore, excited state reactivity of Au22(Lys–Cys–Lys)16 clusters is studied, and formation of type-I reactive oxygen species (ROS) from the excited state of the clusters is observed. The proposed size-focusing procedure in this work can be easily adapted to conventional cluster synthetic methods, such as borohydride reduction, to provide atomically precise clusters.
Show moreOrganizations and authors
Publication type
Publication format
Article
Parent publication type
Journal
Article type
Original article
Audience
ScientificPeer-reviewed
Peer-ReviewedMINEDU's publication type classification code
A1 Journal article (refereed), original researchPublication channel information
Journal
Publisher
Volume
16
Issue
1
Pages
205-211
ISSN
Publication forum
Publication forum level
3
Open access
Open access in the publisher’s service
No
Self-archived
Yes
Other information
Fields of science
Physical sciences; Nanotechnology
Keywords
[object Object],[object Object]
Publication country
United Kingdom
Internationality of the publisher
International
Language
English
International co-publication
Yes
Co-publication with a company
No
DOI
10.1039/d3nr04793h
The publication is included in the Ministry of Education and Culture’s Publication data collection
Yes