After a common pregnancy complication pre-eclampsia (PE) follow-up and early prevention for cardiovascular disease (CVD) in women and their families is important, but personalized CVD risk prediction is needed. We have shown that maternal genes related to blood pressure traits are associated with PE and cardiometabolic function. The paternal effects on PE have been shown, but the underlying biological processes remain poorly understood. The first aim is to stratify the risk of CVDs in women with a history of PE using registry data. The second aim is to study how genetic susceptibility to PE and CVD predict the course of pregnancy and later CVD. The third aim is to include paternal and offspring genetic data to explore the contribution of the family trio to maternal risk of PE and later CVD morbidity in each family member. The data including trios is unique and help to understand complex association of PE with CVD in families and to provide targeted medical follow-up after pregnancy.

2024

2028