undefined

Midlife Cardiovascular Status and Old Age Physical Functioning Trajectories in Older Businessmen

Year of publication

2019

Authors

von Bonsdorff, Mikaela B.; Haapanen, Markus J.; Törmäkangas, Timo; Pitkälä, Kaisu H.; Stenholm, Sari; Strandberg, Timo E.

Abstract

OBJECTIVES. The associations between cardiovascular disease (CVD) risk and later physical functioning have been observed, but only a few studies with follow‐up into old age are available. We investigated the association between cardiovascular status in midlife and physical functioning trajectories in old age. DESIGN. Prospective cohort study. SETTING. Helsinki Businessmen Study. PARTICIPANTS. We studied white men born between 1919 and 1934 in the Helsinki Businessmen Study (HBS, initial n = 3490). MEASUREMENTS. Three CVD status groups were formed based on clinical measurements carried out in 1974: signs of CVD (diagnosed clinically or with changes in ECG, chronic disease present or used medication, n = 563); healthy and low CVD risk (n = 593) and high CVD risk (n = 1222). Of them, 1560 men had data on physical functioning from at least one of four data collection waves between 2000‐2010. Ten questions from the RAND‐36 (SF‐36) survey were used to construct physical functioning trajectories with latent class growth mixture models. Mortality was accounted for in competing risk models. RESULTS. A five‐class solution provided the optimal number of trajectories: “intact,” “high stable,” “high and declining,” “intermediate and declining,” and “consistently low” functioning. Compared with low CVD risk, high CVD risk in midlife decreased the risk of being classified into the intact (fully adjusted β = −3.98; standard error = 2.0; P = .046) relative to the consistently low physical functioning trajectory. Compared with low CVD risk, those with signs of CVD were less likely to follow the intact, high stable, or high and declining relative to the consistently low trajectory (all P < .018). CONCLUSION. Among businessmen, a more favorable CVD profile in midlife was associated with better development of physical functioning in old age.
Show more

Organizations and authors

Helsinki University Hospital Catchment Area

Pitkälä Kaisu H.

Haapanen Markus J.

Strandberg Timo E.

University of Oulu

Strandberg Timo

University of Turku

Stenholm Sari

University of Jyväskylä

Bonsdorff von Mikaela Orcid -palvelun logo

Törmäkangas Timo Orcid -palvelun logo

University of Helsinki

Pitkälä Kaisu H.

Haapanen Markus J.

Strandberg Timo E.

Publication type

Publication format

Article

Parent publication type

Journal

Article type

Original article

Audience

Scientific

Peer-reviewed

Peer-Reviewed

MINEDU's publication type classification code

A1 Journal article (refereed), original research

Publication channel information

Volume

67

Issue

12

Pages

2490-2496

​Publication forum

61819

​Publication forum level

3

Open access

Open access in the publisher’s service

No

Open access of publication channel

Partially open publication channel

Self-archived

Yes

Other information

Fields of science

General medicine, internal medicine and other clinical medicine; Public health care science, environmental and occupational health

Keywords

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Publication country

United States

Internationality of the publisher

International

Language

English

International co-publication

No

Co-publication with a company

No

DOI

10.1111/jgs.16150

The publication is included in the Ministry of Education and Culture’s Publication data collection

Yes