Midlife Cardiovascular Status and Old Age Physical Functioning Trajectories in Older Businessmen
Year of publication
2019
Authors
von Bonsdorff, Mikaela B.; Haapanen, Markus J.; Törmäkangas, Timo; Pitkälä, Kaisu H.; Stenholm, Sari; Strandberg, Timo E.
Abstract
OBJECTIVES. The associations between cardiovascular disease (CVD) risk and later physical functioning have been observed, but only a few studies with follow‐up into old age are available. We investigated the association between cardiovascular status in midlife and physical functioning trajectories in old age. DESIGN. Prospective cohort study. SETTING. Helsinki Businessmen Study. PARTICIPANTS. We studied white men born between 1919 and 1934 in the Helsinki Businessmen Study (HBS, initial n = 3490). MEASUREMENTS. Three CVD status groups were formed based on clinical measurements carried out in 1974: signs of CVD (diagnosed clinically or with changes in ECG, chronic disease present or used medication, n = 563); healthy and low CVD risk (n = 593) and high CVD risk (n = 1222). Of them, 1560 men had data on physical functioning from at least one of four data collection waves between 2000‐2010. Ten questions from the RAND‐36 (SF‐36) survey were used to construct physical functioning trajectories with latent class growth mixture models. Mortality was accounted for in competing risk models. RESULTS. A five‐class solution provided the optimal number of trajectories: “intact,” “high stable,” “high and declining,” “intermediate and declining,” and “consistently low” functioning. Compared with low CVD risk, high CVD risk in midlife decreased the risk of being classified into the intact (fully adjusted β = −3.98; standard error = 2.0; P = .046) relative to the consistently low physical functioning trajectory. Compared with low CVD risk, those with signs of CVD were less likely to follow the intact, high stable, or high and declining relative to the consistently low trajectory (all P < .018). CONCLUSION. Among businessmen, a more favorable CVD profile in midlife was associated with better development of physical functioning in old age.
Show moreOrganizations and authors
Oulu University Hospital Catchment Area
Strandberg Timo
University of Oulu
Strandberg Timo
University of Turku
Stenholm Sari
Publication type
Publication format
Article
Parent publication type
Journal
Article type
Original article
Audience
ScientificPeer-reviewed
Peer-ReviewedMINEDU's publication type classification code
A1 Journal article (refereed), original researchPublication channel information
Parent publication name
Volume
67
Issue
12
Pages
2490-2496
ISSN
Publication forum
Publication forum level
3
Open access
Open access in the publisher’s service
No
Open access of publication channel
Partially open publication channel
Self-archived
Yes
Other information
Fields of science
General medicine, internal medicine and other clinical medicine; Public health care science, environmental and occupational health
Keywords
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Publication country
United States
Internationality of the publisher
International
Language
English
International co-publication
No
Co-publication with a company
No
DOI
10.1111/jgs.16150
The publication is included in the Ministry of Education and Culture’s Publication data collection
Yes