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Schizophrenia polygenic risk score and long-term success in the labour market : A cohort study

Year of publication

2022

Authors

Viinikainen, Jutta; Böckerman, Petri; Hakulinen, Christian; Kari, Jaana, T.; Lehtimäki, Terho; Raitakari, Olli, T.; Pehkonen, Jaakko

Abstract

Employment is rare among people with a schizophrenia diagnosis. Meanwhile, a genetic liability for schizophrenia may hinder labour market performance. We studied how the polygenic risk score (PGS) for schizophrenia related to education and labour market outcomes. We found that a higher PGS was linked to lower educational levels and weaker labour market outcomes as well as a higher likelihood of receiving social income transfers, particularly among men. Assuming that the link is causal, our results indicate that individuals with schizophrenia or schizophrenia-related traits have a weakened ability to fully participate in the labour market, potentially reinforcing social exclusion.
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Organizations and authors

Tampere University Hospital

Lehtimäki Terho Orcid -palvelun logo

Tampere University

Lehtimäki Terho Orcid -palvelun logo

University of Jyväskylä

Pehkonen Jaakko Orcid -palvelun logo

Kari Jaana Orcid -palvelun logo

Viinikainen Jutta Orcid -palvelun logo

Böckerman Petri Orcid -palvelun logo

University of Turku

Raitakari Olli

University of Helsinki

Hakulinen Christian

Publication type

Publication format

Article

Parent publication type

Journal

Article type

Original article

Audience

Scientific

Peer-reviewed

Peer-Reviewed

MINEDU's publication type classification code

A1 Journal article (refereed), original research

Publication channel information

Parent publication name

Journal of Psychiatric Research

Volume

151

Pages

638-641

​Publication forum

61461

​Publication forum level

1

Open access

Open access in the publisher’s service

Yes

Open access of publication channel

Partially open publication channel

License of the publisher’s version

CC BY

Self-archived

Yes

Other information

Fields of science

Economics; Psychology; General medicine, internal medicine and other clinical medicine; Neurology and psychiatry; Public health care science, environmental and occupational health

Keywords

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Publication country

United Kingdom

Internationality of the publisher

International

Language

English

International co-publication

Yes

Co-publication with a company

Yes

DOI

10.1016/j.jpsychires.2022.05.041

The publication is included in the Ministry of Education and Culture’s Publication data collection

Yes