1H NMR Urinary Metabolomic Analysis in Older Adults after Hip Fracture Surgery May Provide Valuable Information for Patient Profiling : A Preliminary Investigation
Year of publication
2022
Authors
Douzi, Wafa; Bon, Delphine; Suikkanen, Sara; Soukkio, Paula; Boildieu, Nadège; Nenonen, Arja; Hupli, Markku; Kukkonen-Harjula, Katriina; Dugué, Benoit
Abstract
In these times of precision and personalized medicine, profiling patients to identify their needs is crucial to providing the best and most cost-effective treatment. In this study, we used urine metabolomics to explore the characterization of older adults with hip fractures and to explore the forecasting of patient outcomes. Overnight urine specimens were collected from 33 patients (mean age 80 ± 8 years) after hip fracture surgery during their stay at a rehabilitation hospital. The specimens were analyzed with 1H NMR spectroscopy. We performed a metabolomics study regarding assessments of frailty status, Functional Independence Measure (FIM), and Short Physical Performance Battery (SPPB). The main metabolic variations concerned 10 identified metabolites: paracetamol derivatives (4 peaks: 2.15 ppm; 2.16 ppm; 7.13 ppm and 7.15 ppm); hippuric acid; acetate; acetone; dimethylamine; glycine; alanine; lactate; valine; TMAO. At baseline, the urinary levels of these metabolites were significantly higher (i) in frail compared with non-frail patients, (ii) in persons with poorer FIM scores, and (iii) in persons with poorer compared SPPB scores. Our findings suggested that patients with increased levels of urine metabolites associated with metabolic, inflammatory, and renal disorders presented clear signs of frailty, impaired functional independence, and poor physical performance. Metabolomics could be a valuable tool to further characterize older adults, especially after major medical events.
Show moreOrganizations and authors
Helsinki University Hospital Catchment Area
Nenonen Arja
Kukkonen-Harjula Katriina
Hupli Markku
Soukkio Paula
Publication type
Publication format
Article
Parent publication type
Journal
Article type
Original article
Audience
ScientificPeer-reviewed
Peer-ReviewedMINEDU's publication type classification code
A1 Journal article (refereed), original researchPublication channel information
Journal
Parent publication name
Publisher
Volume
12
Issue
8
Article number
744
ISSN
Publication forum
Publication forum level
1
Open access
Open access in the publisher’s service
Yes
Open access of publication channel
Fully open publication channel
Self-archived
Yes
Other information
Fields of science
Biochemistry, cell and molecular biology; Health care science; Sport and fitness sciences
Keywords
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Publication country
Switzerland
Internationality of the publisher
International
Language
English
International co-publication
Yes
Co-publication with a company
Yes
DOI
10.3390/metabo12080744
The publication is included in the Ministry of Education and Culture’s Publication data collection
Yes